The movie begins with a flashback to the founding of the Thrombey estate, highlighting the family's wealth, secrets, and scandals over the generations. 

After the mysterious death of Harlan Thrombey Jr., the eccentric detective Benoit Blanc is called to investigate. The will reading unveils twelve beneficiaries, each with their own motives and connections to the family fortune. 

Each beneficiary represents a different branch of the Thrombey family or individuals linked to the estate. As Blanc delves deeper, he uncovers layers of deception, rivalries, and hidden agendas among the heirs. 

One storyline revolves around a cunning art forger within the family who uses the chaos surrounding the inheritance to cover up their illicit activities. 

Another subplot involves a lost manuscript that holds clues to a long-buried family secret, sparking a race among the heirs to decipher its meaning and claim its revelations. 

Blanc discovers a series of cryptic clues left by Harlan Jr. before his death, leading him on a trail of puzzles and enigmas that uncover shocking truths about the Thrombey legacy. 

As alliances shift and betrayals are exposed, Blanc navigates a web of lies and deceit, trying to separate fact from fiction amidst the chaos of the family drama. 

Through meticulous detective work and clever deductions, Blanc unravels the tangled web of mysteries, ultimately revealing the mastermind behind the schemes and the true nature of Harlan Jr.'s demise. 

The movie culminates in a dramatic confrontation where Blanc exposes the culprit behind the elaborate plots, bringing justice to light and resolving the conflicts within the Thrombey family. 

The aftermath of the investigation leaves a lasting impact on the Thrombey family, reshaping their relationships, fortunes, and understanding of their shared history. 

However, amidst the resolutions, hints of unresolved mysteries and lingering secrets suggest that the legacy of the Thrombey estate continues to haunt its descendants.